No, using random number generators does not boost your odds of winning the Mega Millions lottery. The outcome of each Mega Millions drawing is entirely random, and each combination of numbers has the exact same chance of being selected, regardless of how the numbers are chosen. Whether you pick numbers manually, use a random number generator, or opt for a quick pick (where the lottery terminal randomly generates numbers for you), the odds remain unchanged. For Mega Millions, the odds of winning the jackpot are approximately 1 in 302.6 million.